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My suggestion would be to tell Windows to eject the drive, unplug it, and plug it back in. Close any applications that are "looking" at the drive first; even if it is just looking at the directory.
There are times when Windows "remembers" the content of a drive, but does not actually talk to it. You can "read" it in Explorer, but if you actually try to open something on the drive, it isn't available. You may find that Windows says can't safely eject the drive, because it cannot really "see" it anymore to close it properly.
Unplugging and replugging resets the hardware interface, and wakes up Windows to the fact that it needs to re-read the drive.
That didn't seem to help. I'm able to browse to a smaller USB drive (1 TB) and of course the data drive. The one it immediately makes it non-responsive is 4 TB.
I do believe this is some sort of HandBrake failure because browsing to that drive in other programs work fine. Things like saving a file (in Notepad, Excel, Plex playlist, etc) work fine.
The File chooser a Framework control. So if it's causing a freeze, then it's a kernel level event happening and we have no control over that I'm afraid.
That's irrelevant in this instance. Not all apps use the same file chooser, or configure it in the same way. Regardless, a crash there is a Windows / .NET problem, not a HandBrake one.
I'm not sure what to suggest here. There's literally 100 things that could trigger this. From exposure plugins, AV, MRU Lists, last state, file/explorer metadata