Error Message opening file

[Phototaker]

I recorded a TV recording & knocked out the adds using VideoReDo & just saved the file in original format. When I try to open it in Handbrake I get this message.
"An Unknown Error has occured.
System.Reflection.TargetInvocationException: Exception has been thrown by the target of an invocation. ---> System.IO.FileNotFoundException: Could not find file 'C:\Windows\system32\HandBrakeCLI.exe'.
at System.IO.__Error.WinIOError(Int32 errorCode, String maybeFullPath)
at System.IO.FileStream.Init(String path, FileMode mode, FileAccess access, Int32 rights, Boolean useRights, FileShare share, Int32 bufferSize, FileOptions options, SECURITY_ATTRIBUTES secAttrs, String msgPath, Boolean bFromProxy, Boolean useLongPath, Boolean checkHost)
at System.IO.FileStream..ctor(String path, FileMode mode, FileAccess access, FileShare share, Int32 bufferSize, FileOptions options, String msgPath, Boolean bFromProxy)
at System.IO.FileStream..ctor(String path, FileMode mode, FileAccess access, FileShare share)
at HandBrakeWPF.Helpers.CliCheckHelper.CheckCLIVersion() in c:\HandBrake\Hudson\workspace\Release_WindowsGui64\0.9.9\win\CS\HandBrakeWPF\Helpers\CliCheckHelper.cs:line 48
at HandBrakeWPF.ViewModels.MainViewModel.OnLoad() in c:\HandBrake\Hudson\workspace\Release_WindowsGui64\0.9.9\win\CS\HandBrakeWPF\ViewModels\MainViewModel.cs:line 890
--- End of inner exception stack trace ---
at System.RuntimeMethodHandle.InvokeMethod(Object target, Object[] arguments, Signature sig, Boolean constructor)
at System.Reflection.RuntimeMethodInfo.UnsafeInvokeInternal(Object obj, Object[] parameters, Object[] arguments)
at System.Reflection.RuntimeMethodInfo.Invoke(Object obj, BindingFlags invokeAttr, Binder binder, Object[] parameters, CultureInfo culture)
at Caliburn.Micro.ActionMessage.<.cctor>b__d(ActionExecutionContext context) in C:\Projects\Blue Spire\Caliburn.Micro\src\Caliburn.Micro.Silverlight\ActionMessage.cs:line 266
at Caliburn.Micro.ActionMessage.Invoke(Object eventArgs) in C:\Projects\Blue Spire\Caliburn.Micro\src\Caliburn.Micro.Silverlight\ActionMessage.cs:line 228
at System.Windows.Interactivity.TriggerBase.InvokeActions(Object parameter)
at System.Windows.EventRoute.InvokeHandlersImpl(Object source, RoutedEventArgs args, Boolean reRaised)
at System.Windows.UIElement.RaiseEventImpl(DependencyObject sender, RoutedEventArgs args)
at MS.Internal.FrameworkObject.OnLoaded(RoutedEventArgs args)
at System.Windows.BroadcastEventHelper.BroadcastEvent(DependencyObject root, RoutedEvent routedEvent)
at System.Windows.BroadcastEventHelper.BroadcastLoadedEvent(Object root)
at System.Windows.Media.MediaContext.FireLoadedPendingCallbacks()
at System.Windows.Media.MediaContext.FireInvokeOnRenderCallbacks()
at System.Windows.Media.MediaContext.RenderMessageHandlerCore(Object resizedCompositionTarget)
at System.Windows.Media.MediaContext.RenderMessageHandler(Object resizedCompositionTarget)
at System.Windows.Interop.HwndTarget.OnResize()
at System.Windows.Interop.HwndTarget.HandleMessage(WindowMessage msg, IntPtr wparam, IntPtr lparam)
at System.Windows.Interop.HwndSource.HwndTargetFilterMessage(IntPtr hwnd, Int32 msg, IntPtr wParam, IntPtr lParam, Boolean& handled)
at MS.Win32.HwndWrapper.WndProc(IntPtr hwnd, Int32 msg, IntPtr wParam, IntPtr lParam, Boolean& handled)
at MS.Win32.HwndSubclass.DispatcherCallbackOperation(Object o)
at System.Windows.Threading.ExceptionWrapper.InternalRealCall(Delegate callback, Object args, Int32 numArgs)
at MS.Internal.Threading.ExceptionFilterHelper.TryCatchWhen(Object source, Delegate method, Object args, Int32 numArgs, Delegate catchHandler)."

What does that mean & how do I fix it?

Thanks in advance

[Deleted User 13735]

Did you run Quickstream Fix in VRD first? You should.

[Phototaker]

I hadn't because I didn't encountered any problems. What I have done is re import the file made by VRD & it opened without problems but still I requested that it run a Quickstream Fix. This ran & didn't report a problem. It still doesn't open in Handbrake. I have also clicked on the file & asked that VCL player open it. It worked & played but the file size is what I started with.